Nicotine and the Pleasure Factor_2993

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Nicotine and the Pleasure Factor
Nicotine itself is not an addictive substance, but,You are not allowed to view links. Register or Login, it induces addictive tendencies in human beings indirectly. Nicotine is responsible for the release of dopamine, a neurotransmitter connected with pleasure and support in the brain. Nicotine is found in tobacco leaves as a chemical. It is considered to be the main ingredient in cigarettes that leads to addiction as well as diseases in cigarette smokers. It actually mimics the activities of a naturally happening neurotransmitter called acetylcholine. It is there in the human's central nervous system and also the nerve muscle joint of skeletal muscles. Acetylcholine holds the primary responsibility for stimulation, which results in increased heart rates, increased alertness, and faster reaction times.
Since acetylcholine and nicotine happen to be chemically similar in terms of characteristics, they can trigger the same type of cholinergic receptors inside the human brain. The nicotine and acetylcholine receptors comprise various and numerous nerve endings. They,You are not allowed to view links. Register or Login, in turn, will release dopamine as and when they are coupled or bound with nicotine or acetylcholine. Receptors look like cups; they possess the exact dimensions that enable them to fit a neurotransmitter molecule, for instance, acetylcholine. This cup shaped receptors are lined with tips of neurons, otherwise called the nerve endings. As and when the neurotransmitter, acetylcholine, connects with the cup shaped acetylcholine receptors, also called cholinergic receptors, these nerve endings are induced to release dopamine.
A peculiar phenomenon of dopamine starts to develop as the dopamine that gets released from these endings invokes a feeling of satisfaction and pleasure in the individual's or person's brain. The mechanism of reinforcement gets underway when the brain becomes addicted to the pleasure brought about by dopamine that gets released from the cholinergic receptors. This largely means that the brain is constantly looking for ways and means to derive the sensation of pleasure. When this happens, cigarette smokers will continue to smoke tobacco cigarettes so that the nicotine in cigarettes induces the release of dopamine inside the brain cells. This, in turn,You are not allowed to view links. Register or Login, will aid them in their efforts to feel happy every time they pick a cigarette and smoke.
In the case of first-time smokers, only a few cholinergic receptors are made available. This is because acetylcholine needs only the bare minimum amount of receptors provided by nature to carry on with its job. On the other hand,You are not allowed to view links. Register or Login, the increase in the concentration levels of nicotine made available leads to cholinergic receptors becoming desensitized in the presence of too much nicotine in them. This desensitization process again leads to the production and development of more and more cholinergic receptors there. These extra receptors will, before long, become desensitized due to the excess nicotine present there. This process goes on until a stage of equilibrium is reached. Equilibrium is attained and a fixed amount of receptors will be made available so that the tendency to smoke or addiction will stay there. Usually, cigarettes smokers smoke one or two packets every day. They have got the required amount of receptors available to contain two packets of cigarettes in a single day.
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