Talk antisense oligonucleotide _3687

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Talk antisense oligonucleotide
 
 
Were quickly serum nuclease degradation, therefore, the need for antisense oligonucleotide modification, if not modified,You are not allowed to view links. Register or Login, the use of inactivated serum must be heat-treated nuclease (4) Animal detection systems are currently antisense oligonucleotide acid anti-virus laboratory animals,You are not allowed to view links. Register or Login, mostly mice used. Because it requires a small dose of antisense oligonucleotide. It was successfully carried out with the mouse antisense oligonucleotide against tick-borne encephalitis in the experiment. Repeated injection of antisense oligonucleotides, 30 to 0% death of animals exempt from the virus. Antisense oligonucleotide as another sensitive issue of medicinal toxicity. Preliminary acute toxicity tests in mice showed that: there is no modified antisense oligonucleotides and their methylation, thio derivatives toxicity unlikely. At doses less than 40mg/kg, did not observe any symptoms of poisoning. With] 50-300gmol methylated antisense nucleotide inoculated Vero cells. 24 cells did not decrease only slightly Wo-ho-hour less. Toxicity test results of the current is still not enough to the toxicity of antisense oligonucleotides to conclusions. Also need a broader and more in-depth research. But people believe that much less than the toxic dose of antisense oligonucleotide dose that can achieve therapeutic purposes. Antisense oligonucleotide for industrial production and commercial development is also a new and challenging issues. Although highly automated DNA synthesizer has been quite popular. But are used for research into the scale of Taiwan oligonucleotide design. Simply does not apply to industrial production. In addition. Synthetic sources of raw materials and price is a big problem, even with large-scale DNA synthesizer according to the current price of raw materials for clinical dosage units into the antisense oligonucleotide are almost unrealistic. On the current situation, the development of large-scale commercialization of DNA synthesizer more problems than solve the problem of synthetic materials is smaller. However, taking into account the development of modern synthetic chemistry and abundance of natural nucleic acid business resources, the issue of a I8 always resolved in the near future. In short, aside nucleotide antisense medicinal prospects are bright. But to achieve this goal there is much work to be done. In addition to this involves the chemical modification, evaluation of toxicity and mechanism of activity of large-scale preparation and other issues require more detailed studies, route of administration, metabolism,You are not allowed to view links. Register or Login, distribution and other issues are also being explored in the subject. But look at the short antisense oligonucleotide history can so that we fully believe that these new types of drugs will face all the problems but with further research to resolve. Antisense oligonucleotide in the near future to become a new family of clinical medicine. * Overseas exchanges across the Taiwan Strait Seminar on the pharmaceutical industry the second status report Caoshan Xiang Sui (Shanghai Institute of Medical Information Bureau) in mid-June this year. Taiwan pharmaceutical industry guild pharmaceutical industry in Taipei hosted the exchange of cross-strait seminar in the western mainland, including 16 experts attended the meeting. In order to further the exchange of cross-strait issues of mutual interest the pharmaceutical industry. Direct contact with pharmaceutical companies to enhance and promote mutually beneficial cross-strait cooperation on the basis of the joint venture, the Taiwan Pharmaceutical Industry Association and the China Pharmaceutical Industry Association in consultation with the last l0 held in Beijing in late the pharmaceutical industry, the second cross-strait exchanges seminar. The meeting mainly from mainland China State Pharmaceutical Administration of the Ministry of Health system, the State Administration of Traditional systems person in charge of relevant experts and the mainland Pharmaceutical Affairs, Drug Administration approval of new drug research and development of imported drugs. Investment environment in the pharmaceutical industry, Pharmaceutical Market Development Status of Chinese medicine, Chinese medicine, etc. Recent production technology. Taiwan concerned with local conditions present their experience in the implementation of GMP. Overview of Taiwan pharmaceutical companies marketing drugs to treat the mainland market, monitoring in the way new drugs pharmaceutical industry associations in Taiwan to promote the development of Taiwan, the role of the pharmaceutical industry and the pharmaceutical industry on how the two sides work together to express their views among the world pharmaceutical market. Attend the meeting on behalf of 77 people in Taiwan, the mainland also similar number of representatives. Meeting from l0 27 to 29, the meeting was very warm and friendly. October 27 reception held in the afternoon. The responsible officer is to introduce the two sides will see the instrument,You are not allowed to view links. Register or Login, but a meeting 'old friends are warm conversation. New friends like old friends, and some have been eager to explore ways to further exchanges and technical cooperation, I also had the honor to participate in this event, it is seen and heard both inside and outside will be extracted in the post did not attend the meeting for the study with colleagues how to play each other advantages. Park to take a short length of common development, led me to an early pharmaceutical industry in Greater China among the world's advanced nations. Experts on the mainland and the person in charge of the introduction of temporary omitted here 'only to the pharmaceutical industry in Taiwan are summarized below. A basic situation of Taiwan's pharmaceutical industry in Taiwan beginning in the recovery of drugs are very lacking. To meet the needs of the community, pharmaceutical companies are emerged,You are not allowed to view links. Register or Login, to 1948, a l9 a