Berberine prevents type 2 diabetic rats elevated serum β amyloid protein in the

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Berberine prevents type 2 diabetic rats elevated serum β amyloid protein in the mechanism
 
 
Ming : Type 2 DM group brain AchE, BchE activity decreased ,You are not allowed to view links. Register or Login, AB increased , possibly because of AchE, BchE directly involved in the deposition of Ap due . Berberine was reported to inhibit cholinesterase activity in serum ¨, therefore speculated that berberine may inhibit cholinesterase activity in serum of type 2 DM to improve insulin signal transduction defects , thereby improving insulin resistance and high insulin blood Disease, thus reducing the level of blood glucose and AB , then the risk of type 2 DM AchE activity increased when the Why ? its mechanism remains to be discussed ,You are not allowed to view links. Register or Login, it was reported that DM complicated with hyperlipidemia , the fatty acid synthesis and acyl transfer to increase and then produce choline,You are not allowed to view links. Register or Login, such as Ach,You are not allowed to view links. Register or Login, Bch, after both the serum cholinesterase is a major physiological substrate , whereby the time to explain why the risk of AchE activity increased in DM , the reason may be due to an increase in the substrate induced increase in liver enzyme synthesis . The results indicated that berberine has a significantly inhibit AchE activity and reduce the role of A13 levels , whether through the mechanism of insulin signal transduction is ? be verified by further experiments . However, the results suggest that : Berberine has reduced the role of A13 ,You are not allowed to view links. Register or Login, so the prevention and treatment of type 2 DM complicated with AD has important clinical value. [
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