Fox Health: Endometrial cancer patients see new hope as FDA approves 'transforming' immunotherapy drug

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Endometrial cancer patients see new hope as FDA approves 'transforming' immunotherapy drug

The FDA has approved a new drug for some adult patients with endometrial cancer. Jemperli (dostarlimably) — made by U.K. company GSK — is intended for primary advanced or recurrent disease....                        ...                        ...                            ...The U.S. Food and Drug Administration (FDA) has approved a new drug for certain adult patients with You are not allowed to view links. Register or Login.......Jemperli (dostarlimab-gxly) — made by British pharmaceutical company GSK — is intended for people with primary advanced or recurrent forms of the cancer, according to the FDA's Aug. 1 announcement.......It is an immunotherapy-based drug, which means it leverages the body's immune system to attack cancer cells.......You are not allowed to view links. Register or Login......In You are not allowed to view links. Register or Login, Jemperli showed an improved progression-free survival and overall survival for all patients, according to Dr. Brian Slomovitz, director of gynecologic oncology and co-chair of the Cancer Research Committee at Mount Sinai Medical Center in Florida......."This class of drugs has been used in the second-line setting," Slomovitz said — meaning they were only used if a first-line (primary) treatment was not effective or had intolerable side effects......."Moving them to first-line [status] here will yield better outcomes."......This is the third FDA approval this year for immunotherapy in You are not allowed to view links. Register or Login, the doctor noted.......You are not allowed to view links. Register or Login......"This is great news for our patients," Slomovitz told Fox News Digital......."Endometrial cancer has become the leading cause of death over all other gynecologic cancers, including You are not allowed to view links. Register or Login."......Before the immunotherapy options became available, the only treatment for endometrial cancer was chemotherapy alone, Slomovitz said. ......"These results are game-changing — it is unprecedented to have three approvals in such a short period of time."......The most common side effects of all immunotherapy drugs are gastrointestinal, endocrine and You are not allowed to view links. Register or Login, the doctor noted......."Patients should understand that adding immunotherapy to traditional chemotherapy has better results and the toxicity profile is manageable," he added.......For doctors, Slomovitz emphasized the need to adjust quickly and make the newly approved drug a first-line treatment option for their patients.......In June, the FDA approved Merck's Keytruda (pembrolizumab) to be used in combination with chemotherapy for adult patients with primary advanced or recurrent You are not allowed to view links. Register or Login......."The Merck trial (pembrolizumab) showed a significant improvement in progression-free survival for all patients," Slomovitz said.......In that same month, AstraZeneca's Imfinzi (durvalumab) was approved for patients with advanced or recurrent disease who have a certain biomarker.......The AstraZeneca trial also showed improved progression-free survival for all patients. ......All trials for the new You are not allowed to view links. Register or Login were run through the GOG Foundation, which is the largest cooperative group for all gynecologic oncology research, Slomovitz noted. ......You are not allowed to view links. Register or Login, the use of immunotherapy drugs in combination with chemotherapy reduced the risk of disease progression by approximately 70% in patients whose tumors had certain biomarkers.......In other patients without that biomarker, there was still a "clinically and statistically significant improvement in time to progression, which is meaningful for our patients and has now led to FDA approvals in both biomarker settings," Kathleen N. Moore, M.D., co-director of the Stephenson Cancer Center at the University of Oklahoma Health Sciences Center, told Fox News Digital.......You are not allowed to view links. Register or Login......"These studies have transformed outcomes for patients with endometrial cancer and are poised to change the You are not allowed to view links. Register or Login for the better into the future," she added.......Shannon N. Westin, medical director of the Gynecologic Oncology Center at the University of Texas MD Anderson Cancer Center, said she is "thrilled" to have multiple new options for patients with advanced and recurrent endometrial cancer after years with no new therapies......."We no longer have to treat everyone in the same cookie-cutter fashion, and can instead employ precision medicine to improve survival for these survivors."......You are not allowed to view links. Register or LoginYou are not allowed to view links. Register or Login......"The addition of immunotherapy to chemotherapy provided improvement in survival outcomes without a negative impact on You are not allowed to view links. Register or Login," she went on. ......"This is the ideal scenario."......Fox News Digital reached out to GSK for comment....

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