Fox Health: Breast cancer drug could help prolong survival for children with brain tumors, study finds

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Breast cancer drug could help prolong survival for children with brain tumors, study finds

A drug called ribociclib, currently used to treat breast cancer, could prove to be an effective weapon against pediatric high-grade glioma, an aggressive childhood brain cancer, a new study says....                        ...                        ...                            ...A drug called ribociclib, currently used to treat You are not allowed to view links. Register or Login, could slow the progression of certain pediatric high-grade gliomas, an aggressive type of childhood brain cancer, a new study has found.......Ribociclib (brand name Kisqali) is a CDK4/6 inhibitor, a type of drug that targets specific enzymes — including the protein CDK6 — to You are not allowed to view links. Register or Login from growing.......In the study, which was published in the journal Cancer Cell, a 10-year-old patient who had experienced a second relapse of pediatric high-grade glioma — and had no other treatment options — experienced 17 months of "progression-free survival" after taking ribociclib.......You are not allowed to view links. Register or Login......The patient had a diffuse hemispheric glioma (DHG), which typically develops in the frontal, parietal and temporal lobes of the brain......."These very early results are remarkable given the typically poor prognosis for children diagnosed with these aggressive You are not allowed to view links. Register or Login," according to a press release from the Institute of Cancer Research (ICR) in London.......This type of tumor usually progresses within 3½ months of recurrence.......It has been four years since the female patient received her diagnosis. She is currently receiving further treatment, the release stated......."Ribociclib was chosen based on the genetic profile of the patient's tumor, which demonstrated relevant markers," said Dr. Gregory Nalesnik, a pediatric oncologist at Memorial Sloan Kettering Cancer Center in New York, who was not involved in the study but reviewed the findings.......The drug was also shown to be effective in mice — 100% of the mice treated with ribociclib survived for 110 days after treatment, compared to only 25% of the mice who received a placebo.......The study, which was led by ICR and the Dana-Farber Cancer Institute in Boston, was partly funded by The Brain Tumour Charity and Cancer Research UK......."We are finally starting to see more targeted therapies come out for different forms of brain cancer," says senior author Mariella Filbin, M.D., PhD, co-director of the Brain Tumor Center of Excellence at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, in the press release.......You are not allowed to view links. Register or Login......"Our patients really need these new treatment options."......Ribociclib was approved by the U.S. Food and Drug Administration (FDA) in March 2017 for the treatment of certain types of advanced or metastatic breast cancer in postmenopausal women.......High-grade gliomas (HGGs) are aggressive tumors in the brain and spinal cord that can occur in children and adults.......You are not allowed to view links. Register or Login......This type of tumor makes up some 10% of pediatric brain tumors, according to the American Brain Tumor Association (ABTA).......They are generally difficult to treat because they often grow into the tissue of the central nervous system.......In You are not allowed to view links. Register or Login with a high-grade glioma, the overall survival rate is less than two years, with less than 30% of patients surviving for five years.......Current treatments include surgery, You are not allowed to view links. Register or Login, although these drugs have proven more effective for adults than children, noted the ABTA.......Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at You are not allowed to view links. Register or Login, was not involved in the study but shared his opinions on the drug's potential......."This is a targeted therapy that has been used in breast cancer to attack growth factors on the surface of the cancer," he told Fox News Digital. ......"It is now showing some promise in slowing progression of several months in a rare but deadly childhood glioma (malignancy in support cells of the brain)." ......On a wider scale, the drug could target more growth factor proteins on cancer cells, Siegel noted......."This approach may be combined with other treatments, You are not allowed to view links. Register or Login and radiation, to help prolong life," he added.......The study highlights the growing prevalence of targeted therapy, Nalesnik commented......."The use of therapy guided by molecular tumor markers is becoming more and more prevalent in the world of oncology," he told Fox News Digital. ......"Sometimes called 'targeted therapies,' these treatments are much more specific than traditional chemotherapies, which are globally cytotoxic (toxic to living cells) in general." ......Targeted therapies like ribociclib, which are designed to address the root cause of a cancer cell's harmful behavior, often have fewer side effects than conventional chemotherapy, according to Nalesnik.......You are not allowed to view links. Register or Login......While targeted therapies show promise in treating aggressive cancers, experts agree that more research is needed......."Although more clinical trials are needed to lend evidence to efficacy and information about side effects (both short-term and long-term), I applaud the authors in their application of translational research and the use of targeted therapy for You are not allowed to view links. Register or Login," Nalesnik added.......Looking ahead, the researchers hope that this study will pave the way to You are not allowed to view links. Register or Login that include more patients......."This research helps us have a better understanding of what is driving this devastating disease in children," said Dr. Simon Newman, chief scientific officer at The Brain Tumour Charity, in the press release. ......You are not allowed to view links. Register or LoginYou are not allowed to view links. Register or Login......"We know that current treatments are not effective and that finding vulnerabilities in cancer cells could lead to new, targeted treatments to help children live You are not allowed to view links. Register or Login. Although this is very early days, we hope that it will provide some data to inform clinical trials in the future."......Fox News Digital reached out to the study researchers and to ABTA for comment....

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