Ryan's District Boards

"Abnormal GM-CSF signalling is pivotal to a variety of serious and difficult-to-treat diseases," Prof Roberts said.
Pharmaceutical company CSL will use their breakthrough to develop new treatments that stop the protein from being activated,You are not allowed to view links. Register or Login, hindering cancer spread.
The researchers hope their work, published in the journal Cell, will lead to targeted therapies,You are not allowed to view links. Register or Login, more specific to the malfunctioning cells seen in diseases such as leukaemia.
Drugs which use antibody molecules to disrupt the regulator's work are in development at CSL.
In leukaemia, an excessive number of malfunctioning white blood cells are produced because some of the signals coming from the receptor are abnormal.
Professor Michael Parker, from the St Vincent's Institute, said his team established the structure of a receptor that controls the actions of a blood-forming regulator called GM-CSF.
New treatments for leukaemia and asthma are in development after Australian scientists discovered a way to stop the production of malfunctioning blood cells.
"With this discovery,You are not allowed to view links. Register or Login, rational design of targeted therapies can now be accelerated greatly."
Researchers at the St Vincent's Institute in Melbourne and Hanson Institute in Adelaide have unravelled the structure of a protein in the blood control system that is key to some blood and inflammatory disorders.
"Because our discovery shows precisely what the receptor looks like and also how it works, we can now begin to design new drugs to rein in the deadly abnormal blood cells," he said.
At present, many leukaemias are treated with chemotherapy that destroys diseased blood cells and bone marrow as well as normal cells.
"This regulator has been of interest to researchers and clinicians for many years now because its controller or receptor, found on the surface of blood cells, is critical in regulating their many functions," Prof Parker said.
Professor Andrew Roberts, from the Walter and Eliza Hall Institute in Melbourne,You are not allowed to view links. Register or Login, said the find was a "major step forward".
Breakthrough in leukaemia treatment

In an announcement at the Society of Automotive Engineers World Congress in Detroit, the companies say they have requested proposals from 40 research and university groups worldwide, and plan to create five centres of expertise for different parts of the body and two centers for full body models.
AP - An international consortium of nine automakers and two parts suppliers is asking researchers for proposals to develop "virtual humans" - computer programs that will help them design safer cars and trucks.
The Global Human Body Models Consortium LLC says the computer models will provide better simulations of crash injuries than current crash dummies.
The companies which formed the consortium a year ago are DaimlerChrysler, Ford Motor, General Motors, Honda Motor, Hyundai Motor Co, Nissan Motor Corp,You are not allowed to view links. Register or Login, PSA Peugeot-Citroen,You are not allowed to view links. Register or Login, Renault, Takata, Toyota Motor and TRW.
Ford already has a computer model of a mid-sized adult male that it uses to develop car interiors and restraint systems, but the consortium would speed development of models for more body types,You are not allowed to view links. Register or Login, said Ford spokesman Said Deep.
'Virtual humans' to test car safety
The consortium hopes to have the first six computer models,You are not allowed to view links. Register or Login, of small, medium and large males and females, developed by March 2011. The companies will share in the estimated cost of up to $US18 million ($A21.6 million). Additional funding is being sought from other sources including the US government and Michigan Economic Development Corporation, the statement said.
The project will yield sophisticated data that would be backed up by physical tests, said GM spokesman Alan Adler.

Moreover,You are not allowed to view links. Register or Login, the federal coalition has vowed to team up with key crossbench senators to disallow the lower rebate when parliament resumes on Monday week.
HCF says its move means members won't face any additional expenses following Labor's decision to cut the standard government rebate from $624 to $340.
But it's only promised to cover any shortfall until April, when a new benefits schedule will kick in.
HCF says boosting the two benefits will cost $1.7 million a year.
Australia's largest not-for-profit health insurer says it will increase benefits for cataract surgery after the Rudd government last week slashed the Medicare rebate by 45 per cent.
The health fund will also increase benefits for angiograms. The Medicare rebate for those procedures has been cut by 18 per cent.
Health fund vows to cover cataract costs
"Without passing judgment on the government's decision, HCF intends to cover, for a period of up to six months, any increase in out-of-pocket expense for our members caused by the Medicare decision,You are not allowed to view links. Register or Login, so that they are no worse off financially,You are not allowed to view links. Register or Login," HCF chief medical officer Andrew Cottrill said in a statement.
But doctors argue the move will hurt elderly patients.
It says it'll keep on fighting until the original rebate is reinstated.
Health Minister Nicola Roxon says patients wouldn't be left in the lurch with the new $340 rebate if eye doctors simply lowered their fees.
"We will work constructively and in collaboration with relevant medical organisations to agree on a fair cost of providing cataract surgery and angiography, to be covered in our new medical benefit schedules," Dr Cottrill said.
She argues advances in technology means standard cataract surgery takes just 20 minutes,You are not allowed to view links. Register or Login, and doctors are raking in millions as a result of the excessively high Medicare payments.

In this year, four per cent of the population had the disease, up from 1.3 per cent in 1990.
The illness either caused or contributed to one in 11 deaths,You are not allowed to view links. Register or Login, with the rate highest among indigenous Australians and people born in South-East Europe, North Africa and the Middle-East.
"That is fearsome indeed because it's higher than before and far higher then any predictions we've made.
Report author Lynelle Moon said the overall rise was largely driven by an increase in the prevalence of type 2 diabetes, the preventable form of the disease linked to obesity, high cholesterol and high blood pressure.
Nearly a third of people starting treatment for end-stage kidney disease did so because of their diabetes, and almost 3,You are not allowed to view links. Register or Login,400 people with diabetes had a leg amputated.
Diabetes hits a record 1.4m high: report
A new report from the Australian Institute of Health and Welfare (AIHW) has painted the grimmest picture yet of the impact of diabetes,You are not allowed to view links. Register or Login, showing 700,000 people have been clinically diagnosed.
"We know that there is one unknown case for every known case so we now have 1.4 million with the disease," said Prof Zimmet, director of the International Diabetes Institute in Melbourne.
Diabetes specialists have welcomed a recent $200 million federal government initiative to prevent the disease but have cautioned it may not be enough.
Diabetics were twice as likely to have had a heart attack, and four times as likely to have had a stroke.
The figure was "fearsome", according to leading diabetes expert Professor Paul Zimmet whose comprehensive AusDiab study carried out in 2000 found 500,000 had been diagnosed.
The AIHW report, Diabetes: Australian Facts 2008, collates the latest 2004/05 statistics to map the path of the condition.
"It represents the biggest epidemic apart from obesity in Australian history."
"It does indicate that government is starting to identify the problem but these funds may not be sufficient in terms of this latest data," Prof Zimmet said.
The diabetes epidemic has reached a dire new high,You are not allowed to view links. Register or Login, with 1.4 million Australians now believed to have the debilitating disease.
"However, type 1 diabetes and gestational diabetes are also on the rise," Ms Moon said.
The report also found that diabetes was treated in more than half a million hospitalisations in 2004/05, with an impact on total health expenditure of $907 million.

Tips For Planning A Christmas Ski Vacation
Christmas is the perfect time to plan a ski vacation. It’s the peak of winter in most countries and the ski slopes are covered with snow. A white Christmas, the family all together, ski slopes to conquer by day and a warm fire in a ski chalet to look forward to at night; a Christmas ski vacation is the perfect way for any family to spend the Christmas holidays.
Choosing a Ski Resort
Ski slopes in different countries offer very different skiing experiences. In fact, it’s safe to say that no two ski vacations at different ski resorts could ever be the same. Some ski slopes are meant for very experienced skiers whereas others,You are not allowed to view links. Register or Login, which have gentler slopes, are more appropriate for beginners. Ski resorts that offer a variety of slopes of different complexities are best for families with smaller kids.
Your budget is a major factor in deciding which ski resort you and your family choose to spend your Christmas vacation in. A ski-resort is by no means a cheap Christmas vacation idea. Ski resorts vary in their prices and many have peak-season and off-season rates. However, do keep in mind that Christmas is peak season at any ski-resort and their prices are likely to be steepest at this time.
Despite the high prices, all ski resorts almost all over the world are likely to be fully booked during the Christmas holidays, so you need to make your plans much,You are not allowed to view links. Register or Login, much in advance. Doing a search on the internet is the best way to find different ski resorts and to compare the different packages they offer. Remember the earlier you start your search, the more choices you will have to avail of. Short list a few ski resorts that suit your needs and contact them to clarify other queries you may have. Once you’ve found the perfect ski resort that meets all your requirements and is also within your budget you may want to consider paying a down payment in order to book the requisite number of rooms for your family.
It’s never too soon to start looking for you’re the perfect ski resort. Commencing your search a year in advance will give you a head start over all other families who have the same Christmas vacation plans.
Looking for Santa Claus at the ski resort
While looking for the perfect ski resort, don’t forget what this vacation is really all about. A Christmas ski vacation needs to combine the skiing fun with the spirit of Christmas. Without it, the vacation will end up being just a family skiing vacation, fun, but not Christmassy.
When making your enquiries, expand your search to include the Christmas options in and around the area. Find out if there are any community activities that your family can participate in,You are not allowed to view links. Register or Login, even if it is in the town around the resort and not in the resort itself.
Also, you may want to consider taking along stockings and stocking stuffers for the whole family. While carrying gigantic gifts for the children is downright inconvenient,You are not allowed to view links. Register or Login, stockings filled with little gifts are an ideal way of carrying the spirit of Christmas everywhere you go.

Where To Go For Digital Photo Camera Shopping,You are not allowed to view links. Register or Login
Because a digital photo camera can be an expensive item to purchase for recreational use, people take considerable steps to find out where to go digital photo camera shopping.  There are local retailers that are located in mass merchandising stores, where the sales representatives only know the basic features about some of the digital photo cameras that the store sells on a regular basis.
These prospective shoppers of digital photo camera devices might decide on where to go digital photo camera shopping by seeking out the professional advice of photograph developer that is right down the street from his business location.  These photographic technicians might be unable to help you. 
They might be unaware of the different types of digital cameras on the market today.  Their digital camera equipment is commercial sized, and not the kind that you could put in your shirt pocket or carry along in a camera bag.  They might, however, be able to direct you with a local retailer that is fluent in all phases of digital camera operations. 
To learn about where to go digital photo camera shopping,You are not allowed to view links. Register or Login, people will usually choose to self-educate themselves on digital cameras.  They visit information websites that have online course that are free of charge, and find out all of the operating functions of a digital camera and the accessories that are available for it,You are not allowed to view links. Register or Login, before they try to find out where to go digital photo camera shopping anywhere else in town.
Other people like to research digital photo cameras thoroughly and read reviews that are created by other digital photo camera owners.  Not only will these people be able to discuss many pros and cons about the digital photo camera, and the accessories that they recently purchased, but they might also tell you in the review where to go digital photo camera shopping.
More and more, people are being guided to buy digital photo cameras by people who have already purchased and used a certain type of digital photo camera.  Based on their comments, people know where to go digital photo camera shopping and find hard-to-find accessories that are no longer stocked at many major retail shops.
Through Internet marketing campaigns, they might know where to go digital camera shopping and have a discount coupon to use that they received in the mail from these Internet marketing companies.  Membership benefits newsletters from discount shopping clubs might inform their members through information contained in their newsletters,You are not allowed to view links. Register or Login, where to go digital photo camera shopping and get a membership shopping club discount at the same time with a certain retailer.

Rapid Fire Adjustable Ascertain Nonstop Satisfaction,You are not allowed to view links. Register or Login
At the present time the Rapid Fire Adjustable  controllers have acquired to the point where it is basically to have one for gaming lovers if they are going to stay in the ring with a lot of the great challenge. There are lots of industries all over the world are being sold the top quality products but no one can believe these all companies. Now the question is about the best Rapid Fire Adjustable xbox 360 mods as well as the skills of players are playing with rapid fire xbox mods.
There are some chances that you do not know about the hacking of a rapid fire Xbox 360 controller and have a rapid fire mod soldered into it as an automatic mod. There is a possibility that all new mechanical Rapid Fire Adjustable buttons on your xbox mods. Mostly people do this around the method of a bit of soldering. If the situation is that you wants to do it automatically there are a plenty of guide lines for first hand xbox 360 mods. There are lots of Youtube videos are there to help you.
These all will be almost certainly obtain to your place earlier than you could pick up a soldering kit and get information that how to use it with better manners. It does also be not more expensive.
There are no hard and fast rules and regulations to find someone selling a Rapid Fire Adjustable controller in this the market. It is reality that it is kind of hard not to find a vendor who is the right person and provide you the best as you wish. Most of Venders have just pretty legit because for it is an easy buck all over the world. The best vendors of Rapid Fire Adjustable 360 controller know very well that how to change the xbox.
One can also nonconformist out as many of them as they want in a day and they just charge you for shipping and supervising. They also include a little fee for the work involved as well as the original cost of the xbox 360 controller. If the situation is that you want to teach xbox mod physically that how to make them at here I have an idea to exploring and starting a small business off just that one skill that you have. You will be able to knock out the top competition with players who are playing with rapid fire controllers very fairly and quickly if you are a good gamer.
If the situation is that you have a practical experience with electronics and talented in soldering then you can pay money for a kit and install the Rapid Fire Adjustable mod yourself. In case you can get success to installing a kit or a rapid fire xbox 360 then you can pick up some extra money by modding the xbox controllers and selling your services to others who do not know how to install a kit or do the mod by hand.
In caseyou are not feeling relaxed while to doing this,You are not allowed to view links. Register or Login, there are many people who sell the Rapid Fire Adjustable Xbox 360 controllers that have the mod previously installed for you or who will mod your controller for you with no trouble. At this point getting a rapid fire Xbox controller will be a hell of a lot of entertaining and exploration endless possibilities for your opinion.