Diabetes affects male fertility_19746

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We also found that spermatogenesis 20,You are not allowed to view links. Register or Login, a factor unique to the testis and whose function remains unknown, was greatly increased. Taken together, these factors indicate clearly that having diabetes has a direct influence on the health of semen,You are not allowed to view links. Register or Login,” he added.
They are dependent on life style diet, smoking etc and in many diabetic complications are centrally implicated in DNA damage. We believe that they play a similar role in the male reproductive system,” he added.
Over the years possible causes for sperm DNA fragmentation have been suggested but to date the exact mechanism for the damage remains unknown.
Washington, July 10 (ANI): Diabetes has an adverse affect on mens reproduction function, says a new study.

The study was presented at 24th annual conference of the European Society of Human Reproduction and Embryology. (ANI)
“We found a class of compounds known as advanced glycation end products (AGEs) in the male reproductive tract. These are formed as the result of glycation (the addition of sugar),” said Dr. Mallidis, “and accumulate during normal ageing.
The study led by Dr. Con Mallidis from Queen’’s University, Belfast, UK,You are not allowed to view links. Register or Login, has found that that diabetes can cause DNA damage in sperm.
For the study,You are not allowed to view links. Register or Login, the researchers studied semen samples from men with diabetes who were receiving insulin therapy. On initial routine microscopic examination the semen samples appeared normal, apart from a slight decrease in volume.
“But when we looked for DNA damage, we saw a very different picture,” said Dr. Mallidis.
“We were particularly interested to see a fourteen-fold decrease in the expression of a protein called ornithine decarboxylase,You are not allowed to view links. Register or Login, which is responsible for the production of spermine and spermidine, compounds responsible for cell growth that help stabilise the structure of DNA.
“Sperm RNA was significantly altered, and many of the changes we observed are in RNA transcripts involved in DNA repair. And comparison with a database of men of proven fertility confirmed our findings.
Diabetics have a significant decrease in their ability to repair sperm DNA, and once this is damaged it cannot be restored,” he said
Diabetes affects male fertility